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180 words Introduction: 873 words Discussion: 1726 words Abbreviations: AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid), CMPDA (a phenyl-1,4-bis-alkylsulfonamide), CMPDB (a phenyl-1,4-bis-carboxythiophene), deact (deactivation), des (desensitization), CTZ (cyclothiazide), CX614 (pyrrolidino-1,3-oxazino benzo1,4-dioxan-10-one), LBC (ligand-binding core), PDB (Protein Data Bank) This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on May 4, 2011 as DOI: 10.1124/mol.110.070243 at A PE T Jornals on M ay 1, 2016 m oharm .aspeurnals.org D ow nladed from